Graphic representation of the proposed arrangement of the sSMC(22). Schematic ideogram of sSMC(22): linear form of chromosome 22q segments situated vis-à-vis (a) and its ring derivative (b). The red arrows indicating the breakpoints, the black dashed arrow the fusion points, gray and green lined circle the centromeres. Diagram of the amplified 22q 11 interval with most relevant genes (c). Blue segments represent double copy and red segments single copy gains.