Identification of prognostic relevant chromosomal abnormalities in chronic lymphocytic leukemia using microarray-based genomic profiling

Stevens-Kroef, Marian JPL; van den Berg, Eva; Olde Weghuis, Daniel; Geurts van Kessel, Ad; Pfundt, Rolph; Linssen-Wiersma, Matty; Benjamins, Marloes; Dijkhuizen, Trijnie; Groenen, Patricia JTA; Simons, Annet

doi:10.1186/1755-8166-7-3

Molecular Cytogenetics

Table 1 Overview of genetic abnormalites as determined by FISH, MLPA and microarray-based genomic profiling

From: Identification of prognostic relevant chromosomal abnormalities in chronic lymphocytic leukemia using microarray-based genomic profiling

Patient ID	FISH (% of abnormal cells)	MLPA	Microarray-based genomic profiling
			Recurrent	Additional
1	Not done	Normal	Normal
2	Not done	Loss 13q14	Loss 13q14
3	Not done	Loss 13q14*	Loss 13q14*	Loss 6p
3	Not done	Loss 17p13	Loss 17p13	CNLOH 13q
4	Not done	Loss 11q22	Loss 11q22	Gain 2p
		Loss 13q14	Loss 13q14	Loss 6p
				Loss 7q
5	Not done	Gain 12	Gain 12	Loss 1q
6	Not done 13q14	Loss 13q14*	Loss 13q14*
	Normal 11q22
	Normal 17p13
7	Normal 11q22			Loss 1q
	Not done 12	Gain 12	Gain 12
	Loss 17p13 (21%)	Loss 17p13	Loss 17p13
8	Not done	Loss 13q14	Loss 13q14
9	Normal 11q22	Loss 17p13	Loss 17p13	Gain 2p
	Loss 17p13 (21%)			Loss 6q
				Gain 17p11
				Loss 20p
10	Gain 8 (28%)	Loss 17p13	Loss 17p13	Gain 8
	Loss 17p13 (16%)			Gain 17q
	Normal 11q22
11	Loss 11q22 (58%)	Loss 11q22	Loss 11q22	Gain Xq
	Normal CEP 12	Gain 12q		Loss 3q
	Loss 13q14 (28%)	Loss 13q14	Loss 13q14	Loss 11p
	Normal 17p13			Gain 12q
12	Not done	Loss 17p13	Loss 17p13	Gain 3q22
				Loss 6q
				Gain 19p
13	Not done	Normal	Normal
14	Not done	Gain 12	Gain 12
15	Not done	Gain 12	Gain 12	Gain 18
15	Not done	Gain 12	Gain 12	Gain 19
16	Loss 13q14 (75%)	Loss 13q14	Loss 13q14
	Normal 17p13	Loss 17p13 (focal)	Loss 17p13 (focal)
17	Normal 11q22	Not done	Gain 12	CNLOH 2q
	Gain 12 (21%)
	Normal 13q14
	Normal 17p13
18	Normal 11q22	Not done	Loss 13q14	Loss 1q
	Normal 12			Loss 4p
	Loss 13q14 (75%)			Loss 15q15 (MGA)
	Normal 17p13
19	Not done	Not done	Normal
20	Normal 11q22	Not done	? loss 13q14	CNLOH 6q
	Normal 12			CNLOH 20q
	Loss 13q14 (5%)*
	Normal 17p13
21	Normal 11q22	Not done	Loss 13q14	Loss 2p
	Normal 12			Loss 8q
	Loss 13q14 (60%)			Loss 10q24
	Normal 17p13			CNLOH 17p
22	Normal 11q22	Not done	Normal
	Normal 12
	Normal 13q14
	Normal 17p13
23	Loss 11q22 (77%)	Not done	Loss 11q22
	Normal 12		Loss 13q14
	Loss 13q14 (50%)
	Normal 17p13
24	Normal 11q22	Not done	Gain 12	Gain 2q
	Gain 12 (21%)
	Normal 13q14
	Normal 17p13
25	Loss 11q22 (56%)	Not done	Loss 11q22	Gain 2p
	Normal 12			Loss 4q
	Normal 13q14			Loss 5q
	Normal 17p13			CNLOH 7pq
				Loss 10p
				Loss 11q
				Loss 18q
				Gain 21q
26	Normal 11q22	Not done	Gain 12
	Gain 12 (38%)
	Normal 13q14
	Normal 17p13
27	Normal 11q22	Not done	Loss 13q14*
	Normal 12
	Loss 13q14 (86%)*
	Normal 17p13
28	Normal 11q22	Not done	Loss 13q14	Loss 6q
	Normal 12		Loss 17p13	Loss 15q
	Loss 13q14 (33%)			Gain 17q
	Loss 17p13 (39%)

*Bi-allelic loss as determined by FISH (loss of both hybridization signals), MLPA (RCN below 1) or microarray (log2 ratio below 1).
CNLOH: Copy Neutral Loss Of Heterozygosity.

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ISSN: 1755-8166

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