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Figure 1 | Molecular Cytogenetics

Figure 1

From: Identification of prognostic relevant chromosomal abnormalities in chronic lymphocytic leukemia using microarray-based genomic profiling

Figure 1

Examples of microarray-based genomic profiles. Microarray-based genomic profiles obtained using the CytoScan HD and HumanOmnioExpress platforms, showing log2 ratios, the log2 ratios smoothened over 10 probes (S-log2) and allele peaks (AP) (case 21 only). A: loss of the 17p region in case 9 (chromosome 17). B: Focal loss of the TP53 gene in case 16 (showing the chromosome 17p13 region). C: Focal loss of the MGA gene in case 18 (showing chromosome 15q15.1). D: Chromothripsis of chromosome 11 in case 11. E: No abnormalities in the log2 ratio and smoothened log2 ratio in case 21. Instead of the 3 expected allele peaks (AA, AB and BB), a pattern showing mainly the AA and BB alleles is observed on the short arm of chromosome 17, indicating the CNLOH.

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Molecular Cytogenetics

ISSN: 1755-8166