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Table 1 Aneuploidy rates in the AD and normal prefrontal cortex

From: X chromosome aneuploidy in the Alzheimer’s disease brain

Controls

Chromosomes/percent aneuploidy (losses + gains)

No (age, years)

1

7

11

16

17

18

X

Control

AK1(76)

0.8

0.9

0.3

0.4

1.2

1.4

0.9

AK2 (78)

0.9

0.6

1.5

0.6

0.5

1.2

1.6

AK3 (80)

0.5

1.0

0.9

0.6

0.8

0.8

0.7

AK4 (82)

0.3

1.4

0.6

1.6

0.7

1.3

1.2

AK5 (79)

0.6

0.9

0.8

0.8

0.8

1.0

1.4

AK6 (69)

0.2

0.4

0.9

0.5

0.6

0.4

0.8

AK7 (71)

0.4

0.6

0.3

0.4

0.3

0.5

1.2

AK8 (70)

0.3

0.2

0/5

0.6

0.5

0.2

2.6

AK9 (82)

0.6

0.4

0.3

0.7

0.5

0.3

1.2

AK10 (79)

0.5

0.3

0.7

0.2

0.4

1.1

1.6

The mean

0.51

0.67

0.68

0.64

0.63

0.82

1.32

(95% CI)

(0.35-0.67)

(0.40-0.94)

(0.41-0.95)

(0.37-0.91)

(0.44-0.81)

(0.50-1.14)

(0.92-1.71)

AD

AD1 (72)

0.5

1.3

1.7

0.3

0.8

0.5

1.0

AD2 (78)

0.2

1.2

0.7

0.9

0.7

0.3

1.0

AD3 (80)

0.4

2.7

0.5

0.8

1.4

1.4

1.6

AD4 (80)

1.0

0.9

0.9

2.3

0.9

1.1

2.3

AD5 (88)

1.3

2.3

1.6

2.5

1.1

1.6

3.9

AD6(82)

0.9

0.8

0.6

0.7

0.4

0.5

4

AD7 (76)

1.1

0.4

0.6

0.4

0.4

0.3

3.3

AD8 (81)

0.6

0.7

0.4

0.5

0.5

1.4

2.7

AD9 (69)

0.7

0.9

0.8

0.4

1.2

0.6

4.3

AD10 (72)

1.2

1.0

1.1

0.5

1.4

0.9

3.7

The mean

0.79

1.22

0.89

1.53

0.88

0.86

2.78

(95% CI)

(0.53-1.05)

(0.70-1.74)

(0.57-1.21)

(0.72-2.34)

(0.60-1.15)

(0.51-1.21)

(1.88-3.68)

P value (Mann-Whitney U test)

0.075

0.053

0.273

0.597

0.162

0.733

0.013

Shapiro-Wilk’s W test for normality (outliers excluded)

0.838

2.676

0.105

0.731

0.32

0.2

0.226

P value (t test)

0.054

0.047

0.27

0.313

0.106

0.85

0.003

  1. (2000 cells per chromosome were scored for each sample; a P value of less than 0.05 was considered as significant; Mann-Whitney U-test for independent groups).
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Molecular Cytogenetics

ISSN: 1755-8166