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Table 1 Aneuploidy rates in the AD and normal prefrontal cortex

From: X chromosome aneuploidy in the Alzheimer’s disease brain

Controls Chromosomes/percent aneuploidy (losses + gains)
No (age, years) 1 7 11 16 17 18 X
Control
AK1(76) 0.8 0.9 0.3 0.4 1.2 1.4 0.9
AK2 (78) 0.9 0.6 1.5 0.6 0.5 1.2 1.6
AK3 (80) 0.5 1.0 0.9 0.6 0.8 0.8 0.7
AK4 (82) 0.3 1.4 0.6 1.6 0.7 1.3 1.2
AK5 (79) 0.6 0.9 0.8 0.8 0.8 1.0 1.4
AK6 (69) 0.2 0.4 0.9 0.5 0.6 0.4 0.8
AK7 (71) 0.4 0.6 0.3 0.4 0.3 0.5 1.2
AK8 (70) 0.3 0.2 0/5 0.6 0.5 0.2 2.6
AK9 (82) 0.6 0.4 0.3 0.7 0.5 0.3 1.2
AK10 (79) 0.5 0.3 0.7 0.2 0.4 1.1 1.6
The mean 0.51 0.67 0.68 0.64 0.63 0.82 1.32
(95% CI) (0.35-0.67) (0.40-0.94) (0.41-0.95) (0.37-0.91) (0.44-0.81) (0.50-1.14) (0.92-1.71)
AD
AD1 (72) 0.5 1.3 1.7 0.3 0.8 0.5 1.0
AD2 (78) 0.2 1.2 0.7 0.9 0.7 0.3 1.0
AD3 (80) 0.4 2.7 0.5 0.8 1.4 1.4 1.6
AD4 (80) 1.0 0.9 0.9 2.3 0.9 1.1 2.3
AD5 (88) 1.3 2.3 1.6 2.5 1.1 1.6 3.9
AD6(82) 0.9 0.8 0.6 0.7 0.4 0.5 4
AD7 (76) 1.1 0.4 0.6 0.4 0.4 0.3 3.3
AD8 (81) 0.6 0.7 0.4 0.5 0.5 1.4 2.7
AD9 (69) 0.7 0.9 0.8 0.4 1.2 0.6 4.3
AD10 (72) 1.2 1.0 1.1 0.5 1.4 0.9 3.7
The mean 0.79 1.22 0.89 1.53 0.88 0.86 2.78
(95% CI) (0.53-1.05) (0.70-1.74) (0.57-1.21) (0.72-2.34) (0.60-1.15) (0.51-1.21) (1.88-3.68)
P value (Mann-Whitney U test) 0.075 0.053 0.273 0.597 0.162 0.733 0.013
Shapiro-Wilk’s W test for normality (outliers excluded) 0.838 2.676 0.105 0.731 0.32 0.2 0.226
P value (t test) 0.054 0.047 0.27 0.313 0.106 0.85 0.003
  1. (2000 cells per chromosome were scored for each sample; a P value of less than 0.05 was considered as significant; Mann-Whitney U-test for independent groups).