Figure 1
From: X chromosome aneuploidy in the Alzheimer’s disease brain
Molecular neurocytogenetic analyses of the AD brain. (A) multiprobe (two-probe) and quantitative FISH using DNA probes for chromosomes 1 (two red signals/D1Z1) and X (one green signal DXZ1/relative intensity is 2120 pixels) demonstrating true X chromosome monosomy; (B) multiprobe (two-probe) and quantitative FISH using DNA probes for chromosomes 1 (two red signals/D1Z1) and X (one green signal DXZ1/relative intensity is 4800 pixels) demonstrating overlapping of two X chromosome signals, but not a chromosome loss; (C) ICS-MCB with a probe set for chromosome X showing one nucleus bearing two chromosomes X and another nucleus bearing single chromosome X.