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Figure 1 | Molecular Cytogenetics

Figure 1

From: X chromosome aneuploidy in the Alzheimer’s disease brain

Figure 1

Molecular neurocytogenetic analyses of the AD brain. (A) multiprobe (two-probe) and quantitative FISH using DNA probes for chromosomes 1 (two red signals/D1Z1) and X (one green signal DXZ1/relative intensity is 2120 pixels) demonstrating true X chromosome monosomy; (B) multiprobe (two-probe) and quantitative FISH using DNA probes for chromosomes 1 (two red signals/D1Z1) and X (one green signal DXZ1/relative intensity is 4800 pixels) demonstrating overlapping of two X chromosome signals, but not a chromosome loss; (C) ICS-MCB with a probe set for chromosome X showing one nucleus bearing two chromosomes X and another nucleus bearing single chromosome X.

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