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Table 2 Biological process of altered genes identified by MLPA in pediatric glioma and of neighbour genes located in the critical deleted regions

From: Homozygous deletion of TNFRSF4, TP73, PPAP2B and DPYD at 1p and PDCD5 at 19q identified by multiplex ligation-dependent probe amplification (MLPA) analysis in pediatric anaplastic glioma with questionable oligodendroglial component

Gene

Biological process

Chromosomal region

Neighbor genes

Biological process

TNFRSF4

Inflammatory and immune response

01p36

TNFRSF18

Apoptosis

   

TTLL10

Protein polyglycylation

   

SDF4

UV protection

TP73

DNA damage response

01p36.3

ARHGEF16

Apoptosis

   

LRRC47

Translation

   

SMIM1

 
   

WRAP73

 
   

TPRG1L

Synapse

   

MEGF6

Calcium ion binding

PPAP2B

Blood vessel development

01pter-p22.1

PRKAA2

Protein phosphorylation

   

C1orf168

 

DPYD

Purine base catabolic process

01p22

PTBP2

mRNA processing

PDCD5

Apoptosis

19q12-q13.1

ANKRD27

Early endosome to late endosome transport

   

DPY19L3

 
   

CEP89

 
   

SLC7A9

Protein complex assembly

   

TDRD12

 
   

NUDT19

 
   

RGS9BP

Negative regulation of signal transduction

BAX

Apoptosis

19q13.3-q13.4

FTOL

 
   

NTN5

 
   

PP1R15A

Apoptosis

   

NUCB1

 
   

CD37

Regulation of humoral immune response

   

PPFIA3

Neurotransmitter secretion

   

CGB

 
   

TYS1

Apoptosis

   

DHDH

 
  1. Only the most nearby protein-coding genes were selected.