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Table 2 Biological process of altered genes identified by MLPA in pediatric glioma and of neighbour genes located in the critical deleted regions

From: Homozygous deletion of TNFRSF4, TP73, PPAP2B and DPYD at 1p and PDCD5 at 19q identified by multiplex ligation-dependent probe amplification (MLPA) analysis in pediatric anaplastic glioma with questionable oligodendroglial component

Gene Biological process Chromosomal region Neighbor genes Biological process
TNFRSF4 Inflammatory and immune response 01p36 TNFRSF18 Apoptosis
    TTLL10 Protein polyglycylation
    SDF4 UV protection
TP73 DNA damage response 01p36.3 ARHGEF16 Apoptosis
    LRRC47 Translation
    SMIM1  
    WRAP73  
    TPRG1L Synapse
    MEGF6 Calcium ion binding
PPAP2B Blood vessel development 01pter-p22.1 PRKAA2 Protein phosphorylation
    C1orf168  
DPYD Purine base catabolic process 01p22 PTBP2 mRNA processing
PDCD5 Apoptosis 19q12-q13.1 ANKRD27 Early endosome to late endosome transport
    DPY19L3  
    CEP89  
    SLC7A9 Protein complex assembly
    TDRD12  
    NUDT19  
    RGS9BP Negative regulation of signal transduction
BAX Apoptosis 19q13.3-q13.4 FTOL  
    NTN5  
    PP1R15A Apoptosis
    NUCB1  
    CD37 Regulation of humoral immune response
    PPFIA3 Neurotransmitter secretion
    CGB  
    TYS1 Apoptosis
    DHDH  
  1. Only the most nearby protein-coding genes were selected.