Figure 5

NimbleGen ISCA plus CGX design profile for X chromosome. a.) The ideogram (below: black, grey and white bars) delineates genomic regions with the cytogenetic bands on the X chromosome. An 67.355 Mb sized loss on chromosome Xq21.3-q28 for the female patient and a black rectangle indicate the length of the loss. b.) Array-CGH workflow. The CGX ISCA plus array showed a 67.355-Mb loss which presented one copy. The 67.355 Mb deleted chromosome segment (GRCh37/hg19; ChrX: 87842016–155255380) is denoted by a bar red line below zero. The blue and yellow dots depict the normalized ration on every probe on the X chromosome. c.) Schematic representation of the chrXq21.3-q28 enlarged region. d.) Next the ideogram listed genes and positions which are affected this patient. This affected region contains 1818 genes and we visualized some of them. We signed with bold font those genes, which can x play a roll to induce the POF/POI phenotype.