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Figure 5 | Molecular Cytogenetics

Figure 5

From: Atypical rearrangement involving 3′-IGH@ and a breakpoint at least 400 Kb upstream of an intact MYC in a CLL patient with an apparently balanced t(8;14)(q24.1;q32) and negative MYC expression

Figure 5

In Silico Mapping of the Translocation Breakpoint Upstream of 5’-MYC-3’ Reveals a Class III Breakpoint and a Region that Contains SNPs associated with Susceptibility Risk Loci for different types of cancer including CLL, prostate, colorectal, bladder, or breast cancer. The farthest probe upstream of 5’ of MYC is the Spectrum Orange of the MYC break apart probe (upper panel) (adopted from Abbott Vysis website for FISH probes). We plotted the base coordinates for WI-1203 STS marker and the 5’ of MYC (see inlet) into the UCSC Genome Browser (hg19) and determine the distance, RefSeq genes (POUF51B and LOC727677), STS markers and SNPs within this interval. The translocation breakpoint (with lightning icon) is centromeric of WI-1203 and about ~400 Kb upstream of 5’-MYC, a Class III breakpoint. We extended the breakpoint further upstream to show ~629 Kb region containing SNPs in different regions of the interval (R1, R2, R3 and CLL) that confer susceptibility risks for cancer [26, 28].

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Molecular Cytogenetics

ISSN: 1755-8166