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Figure 3 | Molecular Cytogenetics

Figure 3

From: Atypical rearrangement involving 3′-IGH@ and a breakpoint at least 400 Kb upstream of an intact MYC in a CLL patient with an apparently balanced t(8;14)(q24.1;q32) and negative MYC expression

Figure 3

Interphase and Sequential Metaphase FISH in our Patient’s Peripheral Blood using our CLL Panel. A-B: Interphase Nuclei FISH detects: (A) deletion of 13q14.3 (D13S319) (2G1R2A), and (B) deletion of 11q22.3 (2G1R). The signal patterns for chromosome 12 centromere, 13q34 and 17p13.1 are normal. C-D: Sequential FISH on the metaphase cell with t(8;14) using: (A) ATM (green)/TP53 (red) specific probes reveals a loss of one ATM signal (2G1R), and (B) with 13q14.3/13q34 specific probes did not reveal a deletion of 13q14.3 in this cell. These findings indicate two separate abnormal clones, one with t(8;14) and 11q deletion, and another with 13q14.3 deletion.

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Molecular Cytogenetics

ISSN: 1755-8166