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Figure 12 | Molecular Cytogenetics

Figure 12

From: Individual karyotypes at the origins of cervical carcinomas

Figure 12

Karyotype arrays of two morphological variants of the cervical carcinoma SW-756. The table of chromosomes and the arrays of the SW-756 variants show that the total chromosome number of the round (C1) SW-756 clone is 80±3 and that of the fusiform (C2) clone is 82±2. Thus both clones are quasi-clonal. The table also shows that copy numbers of 55-100% of chromosomes of both clones formed parallel lines in the arrays. Non-clonal chromosomes included intact chromosomes with near-clonal copy numbers and new non-clonal marker chromosomes found in three and five of 20 SW-756 cells respectively. Comparison of the karyotype arrays of the two morphological SW-756 variants indicate that the two clones are phylogenetically closely related, but differed in the clonal copy numbers of seven intact chromosomes, and in five highly clonal round C1-specific and four fusiform C2-specific markers. Comparison of the SW-756 arrays with the arrays of the six carcinomas shown above in Figures 6, 7, 8, 9, 10 and 11 reveals again at a glance that all seven carcinomas have individual clonal karyotypes.

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