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Table 1 Cases of myeloid malignancies with presence or gain of i(5)(p10) described in the literature

From: A case of acute myeloid leukemia (AML) with an unreported combination of chromosomal abnormalities: gain of isochromosome 5p, tetrasomy 8 and unbalanced translocation der(19)t(17;19)(q23;p13)

Case FAB type Karyotype +i(5)(p10) +8 References
1 AML-M1 47,XX,t(1;19)(p22;q13),del(2)(q33),del(3)(q21),+i(5)(p10),add(6)(p2?3) +   Choi et al., 2007 [14]
2 AML-M1 48,XX,+8,+i(8)(q10)/49,idem,+i(5)(p10) + + Calabrese et al., 1992 [15]
3 AML-M2a 46,XX,del(9)(q12q33)/46,idem,der(5)t(5;6)(q23;q22),der(6)t(5;6)(q35;q22),del(17)(p11)/46,idem,add(1) (p11),der(2)t(1;2)(p2?;p2?),der(2)t(2;12)(p2?;q14),del(5)(q14q34),i(5)(p10),add(12)(q2?),del(17)/46, idem,dic(4;5)(q11;q11),-5,+8,der(12)t(5;12)(q1?1;p1?)t(5;17)(q23;q11),-17,+mar/46,idem,dic(4;5),-5,+8, add(11)(p?),der(12)t(5;12)t(5;17),-17,-20,+r,+mar   + Herry et al., 2007 [16]
Herry et al., 2010 [13]
4 AML-M2 46,XY,i(5)(p10),+der(12)t(1;12)(p11;p13),-13,-17,?add(22)(q13),+der(?)t(?;13)(?;q12)/47,idem, del(1)(q11),+mar/47,idem,add(8)(q22),+mar    Tamura et al., 1995 [17]
5 AML-M3 47,XX,+i(5)(p10),ins(15;17)(q22;q21q21)/48,idem,+9 +   Goldschmidt et al., 2010 [18]
6 AML-M4 47,XY,+8/47,XY,+i(5)(p10)/48,XY,+i(5)(p10),+8 + + Panani, 2006 [12]
7 AML-M4 43-45,XY,add(2)(p?21),i(5)(p10),-7,+8,-12,-16,-17,add(17)(p11),+1-3mar,inc   + El Rifai, 1997 [19]
8 AML-M5 46,XX,t(6;14)(p12;q32),t(8;16)(p11;p13)/45,idem,-10/47,idem,+i(5)(p10) +   Schmidt et al., 2004 [20]
9 AML-M5 46,X,del(Y)(q12),+der(2)t(2;14)(p11;q11),+i(5)(p10),+8,del(9)(q13),t(9;10)(q13;p11),del(10)(p11),-13,-14 + + Yunis et al., 1984 [21]
10 AML-M5a 47,XX,+i(5)(p10),t(8;16)(p11;p13) +   Gervais et al., 2008 [22]
11 AML-M5a 48,XX,+i(5)(p10),+8 + + Schoch et al., 2001 [11]
12 AML-M5a 48,XX,+i(5)(p10),+8 + + Schoch et al., 2001 [11]
13 AML-M5a 48,XX,+i(5)(p10),+8,der(14)t(1;14)(q11;p11) + + Schoch et al., 2001 [11]
14 AML-M5b 50,XY,+der(5)t(1;5)(p13;q11),+i(5)(p10),add(6)(q25),+8,+der(8)t(8;14)(p11;q11),-14,del(17)(p11),+20 + + Slovak et al., 1991 [23]
15 AML-M6 46,XY,i(5)(p10),-10,add(12)(p?),-13,-14,-15,+4mar/46,XY,i(5),-6,-7,-17,-19, +rx3,+mar    Herry et al., 2010 [13]
16 s-AMLb 48,XY,+1,der(1;13)(q10;q10),+i(5)(p10),+8 + + Flach et al., 2011 [24]
17 MDS 46,XX,i(5)(p10)    Douet-Guilbert et al., 2011 [25]
18 MDS 46,XY,i(5)(p10),+8   + Jimenez-Souza et al., 2010 [26]
19 RAEB-1 46-48,XX,i(5)(p10),+6,add(6)(p?)x2,-7,add(9),add(14)(p?),+mar    Lessard et al., 2007 [27]
20 RARS 47,XY,i(5)(p10),del(12)(p11),+i(12)(p10)    Christodoulou et al., 2004 [28]
21 RCMD 44,X,-Y,i(5)(p10),inc    Reddi et al., 2012 [29]
22 RCMD 46,XX,i(5)(p10),add(6)(p?),?i(9)(p?),add(14)(p10)/47,idem,+add(6)    Herry et al., 2010 [13]
23 CML 47,XX,+X,der(1)t(1;5)(q36;q11),t(3;9;22;12)(q12;q34;q11;p13),-5,i(5)(p10),+8   + Markovic et al., 2000 [30]
  1. s-AML, secondary acute myeloid leukemia; MDS, myelodysplastic syndrome; RAEB-1, refractory anemia with excess blasts-1; RARS, refractory anemia with ring sideroblasts; RCMD, refractory cytopenia with multilineage dysplasia.
  2. Bold letters highlight gain of isochromosome 5p and/or trisomy 8.
  3. aThis case was reported by Herry et al. as patient 16 in 2007 [16] and as patient 5 in 2010 [13].
  4. bThis case was initially classified as RAEB-2.