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Table 1 Cases of myeloid malignancies with presence or gain of i(5)(p10) described in the literature

From: A case of acute myeloid leukemia (AML) with an unreported combination of chromosomal abnormalities: gain of isochromosome 5p, tetrasomy 8 and unbalanced translocation der(19)t(17;19)(q23;p13)

Case

FAB type

Karyotype

+i(5)(p10)

+8

References

1

AML-M1

47,XX,t(1;19)(p22;q13),del(2)(q33),del(3)(q21),+i(5)(p10),add(6)(p2?3)

+

 

Choi et al., 2007 [14]

2

AML-M1

48,XX,+8,+i(8)(q10)/49,idem,+i(5)(p10)

+

+

Calabrese et al., 1992 [15]

3

AML-M2a

46,XX,del(9)(q12q33)/46,idem,der(5)t(5;6)(q23;q22),der(6)t(5;6)(q35;q22),del(17)(p11)/46,idem,add(1) (p11),der(2)t(1;2)(p2?;p2?),der(2)t(2;12)(p2?;q14),del(5)(q14q34),i(5)(p10),add(12)(q2?),del(17)/46, idem,dic(4;5)(q11;q11),-5,+8,der(12)t(5;12)(q1?1;p1?)t(5;17)(q23;q11),-17,+mar/46,idem,dic(4;5),-5,+8, add(11)(p?),der(12)t(5;12)t(5;17),-17,-20,+r,+mar

 

+

Herry et al., 2007 [16]

Herry et al., 2010 [13]

4

AML-M2

46,XY,i(5)(p10),+der(12)t(1;12)(p11;p13),-13,-17,?add(22)(q13),+der(?)t(?;13)(?;q12)/47,idem, del(1)(q11),+mar/47,idem,add(8)(q22),+mar

  

Tamura et al., 1995 [17]

5

AML-M3

47,XX,+i(5)(p10),ins(15;17)(q22;q21q21)/48,idem,+9

+

 

Goldschmidt et al., 2010 [18]

6

AML-M4

47,XY,+8/47,XY,+i(5)(p10)/48,XY,+i(5)(p10),+8

+

+

Panani, 2006 [12]

7

AML-M4

43-45,XY,add(2)(p?21),i(5)(p10),-7,+8,-12,-16,-17,add(17)(p11),+1-3mar,inc

 

+

El Rifai, 1997 [19]

8

AML-M5

46,XX,t(6;14)(p12;q32),t(8;16)(p11;p13)/45,idem,-10/47,idem,+i(5)(p10)

+

 

Schmidt et al., 2004 [20]

9

AML-M5

46,X,del(Y)(q12),+der(2)t(2;14)(p11;q11),+i(5)(p10),+8,del(9)(q13),t(9;10)(q13;p11),del(10)(p11),-13,-14

+

+

Yunis et al., 1984 [21]

10

AML-M5a

47,XX,+i(5)(p10),t(8;16)(p11;p13)

+

 

Gervais et al., 2008 [22]

11

AML-M5a

48,XX,+i(5)(p10),+8

+

+

Schoch et al., 2001 [11]

12

AML-M5a

48,XX,+i(5)(p10),+8

+

+

Schoch et al., 2001 [11]

13

AML-M5a

48,XX,+i(5)(p10),+8,der(14)t(1;14)(q11;p11)

+

+

Schoch et al., 2001 [11]

14

AML-M5b

50,XY,+der(5)t(1;5)(p13;q11),+i(5)(p10),add(6)(q25),+8,+der(8)t(8;14)(p11;q11),-14,del(17)(p11),+20

+

+

Slovak et al., 1991 [23]

15

AML-M6

46,XY,i(5)(p10),-10,add(12)(p?),-13,-14,-15,+4mar/46,XY,i(5),-6,-7,-17,-19, +rx3,+mar

  

Herry et al., 2010 [13]

16

s-AMLb

48,XY,+1,der(1;13)(q10;q10),+i(5)(p10),+8

+

+

Flach et al., 2011 [24]

17

MDS

46,XX,i(5)(p10)

  

Douet-Guilbert et al., 2011 [25]

18

MDS

46,XY,i(5)(p10),+8

 

+

Jimenez-Souza et al., 2010 [26]

19

RAEB-1

46-48,XX,i(5)(p10),+6,add(6)(p?)x2,-7,add(9),add(14)(p?),+mar

  

Lessard et al., 2007 [27]

20

RARS

47,XY,i(5)(p10),del(12)(p11),+i(12)(p10)

  

Christodoulou et al., 2004 [28]

21

RCMD

44,X,-Y,i(5)(p10),inc

  

Reddi et al., 2012 [29]

22

RCMD

46,XX,i(5)(p10),add(6)(p?),?i(9)(p?),add(14)(p10)/47,idem,+add(6)

  

Herry et al., 2010 [13]

23

CML

47,XX,+X,der(1)t(1;5)(q36;q11),t(3;9;22;12)(q12;q34;q11;p13),-5,i(5)(p10),+8

 

+

Markovic et al., 2000 [30]

  1. s-AML, secondary acute myeloid leukemia; MDS, myelodysplastic syndrome; RAEB-1, refractory anemia with excess blasts-1; RARS, refractory anemia with ring sideroblasts; RCMD, refractory cytopenia with multilineage dysplasia.
  2. Bold letters highlight gain of isochromosome 5p and/or trisomy 8.
  3. aThis case was reported by Herry et al. as patient 16 in 2007 [16] and as patient 5 in 2010 [13].
  4. bThis case was initially classified as RAEB-2.