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Figure 3 | Molecular Cytogenetics

Figure 3

From: A case of acute myeloid leukemia (AML) with an unreported combination of chromosomal abnormalities: gain of isochromosome 5p, tetrasomy 8 and unbalanced translocation der(19)t(17;19)(q23;p13)

Figure 3

FISH analysis using locus specific probes for chromosome 5p/5q and a centromer enumeration probe for the identification of chromosome 8. Hybridization signals on an inverted DAPI counterstain metaphase spread show four blue signals indicative of tetrasomy 8, two green signals on the supernumerary isochromosome 5p and two green and two red signals on the normal chromosomes 5. The insert shows a representative interphase-FISH image of sideline 1/subclone 1 with the signal pattern of two red and four green dots (arrow-heads) indicating gain of i(5)(p10) and four blue dots indicating tetrasomy 8 (arrows).

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Molecular Cytogenetics

ISSN: 1755-8166