Figure 2
From: Myeloproliferative neoplasm with ETV6-ABL1 fusion: a case report and literature review
FISH mapping of 9q34 and 12p13 regions in t (9;12)(q34;p13). (a) Diagram of 9q34 (top) and 12p13 chromosome regions with a map of the BAC clones used for FISH analysis. Red arrows indicate breakpoint positions in 9q34.12, 9q34.3 and 12p13.2; (b) Exons 2-11 of the ABL1 (RP11-83 J21 in red) on der(9)t(9;12) co-localizing with the 5’ part of the ETV6 gene (RP11-418C2 in green) and (c) The break at 9q34.3, 5.63 Mb distal to ABL1, is flanked proximally by RP11-707O3 (green) which houses the NOTCH1 gene and remains in der(9)t(9;12) and distally by RP11-678D10 (red) which has moved to der(12)t(9;12) (arrowed).