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Figure 3 | Molecular Cytogenetics

Figure 3

From: Early detection of Angelman syndrome resulting from de novo paternal isodisomic 15q UPD and review of comparable cases

Figure 3

Genetic analysis of the affected family using polymorphic STR markers MMTS2, D15S119 and D15S1028 for the fibrillin-1 gene. Marker analysis of the patient (III/1), his parents (II/1, II/2), maternal aunts (II/3, II/4, II/5), maternal grandparents (I/3, I/4), and paternal grandparents (I/1, I/2) was performed by ALFexpress gel electrophoresis. The patient is homozygous for polymorphisms occurring in the father but not the mother, indicating that both arms of the aberrant chromosome 15 were of paternal origin.

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Molecular Cytogenetics

ISSN: 1755-8166