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Figure 4 | Molecular Cytogenetics

Figure 4

From: Molecular topography of the MED12-deleted region in smooth muscle tumors: a possible link between non-B DNA structures and hypermutability

Figure 4

A: For detailed analysis the MED12 segment affected by deletions was upstream and downstream extended by seven and six bp, respectively each and then subdivided into subsegments of five nt. each. For illustration, these 5 nt. sliding windows are shown in pink and green, respectively. B: Folded structure of the DNA-segment covering the MED12-deletions seen in uterine smooth muscle tumors. For prediction the DNA segment affected by deletions (c.f. Figures 1 and 2) has been extended by seven and six nt., respectively, on both sides. Of the predicted structures by m-fold that with the lowest free energy (given as kcal/mol) is given. For analyses of non-randomly distribution, breakpoints within the five subsegment nt.-windows are corresponding to A. Breakpoints within each subsegment are given by triangles.

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