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Table 5 Genes implicated in causing cancer located on the chromosome fragments 10q24 and 16q24 (reviewed and summarized from source: )

From: Prolonged exposure to acid and bile induces chromosome abnormalities that precede malignant transformation of benign Barrett’s epithelium

Gene name Location Cancer connection
BTRC (beta-transducin repeat containing) 10 q24 Several mutations of the gene have been reported in prostrate [45], breast [46] and gastric cancers [47]. Overexpression of the protein was detected in melanomas [48], hepatoblastomas [49] and colorectal [50], pancreatic [51] and breast carcinomas [52].
LOXL4 (lysyl oxidase-like 4)   LOXL4 mRNA was expressed in MDA-MB-231 highly invasive breast cancer cells, but not in poorly invasive and non-metastatic breast cancer cells MCF7 and T47D [53]. LOXL4 was over-expressed in most invasive HNSSC primary or metastatic tumors and cell lines, primary tumors of oral cavity as well as thyroid gland whereas no expression was detected in normal epithelial cells [54].
NFkappa B2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)   rearrangement of NFkappa b2 gene locus has been found in many forms of lymphomas [55].
PAX2 (Paired box gene 2)   It has been proposed as a useful marker of prostate cancer as well as predictor of severity of kidney cancers [56]
PDCD4 (Programmed Cell Death 4)   Expression attenuated with progression in human tumors of the lung, colon, prostate and breast; diagnostic and prognostic for colon cancer staging with decreased expression in adenomas and a further decrease in stage 1 adenocarcinomas.
CBFA2T3 (core-binding factor, runt domain, alpha subunit 2 translocated to 3) Chromosome 16 q24 Loss of normal function of CBFA2T3 may be a key event in the early stage of breast cancer [57]. LOH on the whole 16q22-qter region is frequently detected in breast and prostate cancer [58].
CDT1 (chromatin licensing and DNA replication factor 1)   CDT1 is a potential oncogene, highly expressed in cancer cell lines CaSki, HeLa, LNcap, MCF7, MDAMB231, and Saos.
FBXO31 (F-box protein 31)   Tumor suppressor down-regulated in breast cancer cell lines relative to normal breast expression and cause G1 phase cell cycle arrest of the MDA-MB-468 cell line. This region is frequently deleted in several human cancers causing loss of heterozygosity [59].