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Figure 5 | Molecular Cytogenetics

Figure 5

From: Chromosome anomalies in bone marrow as primary cause of aplastic or hypoplastic conditions and peripheral cytopenia: disorders due to secondary impairment of RUNX1 and MPL genes

Figure 5

Mitosis cut-outs with FISH results of patient 3. A: the arrow indicates the signal of probe RP11-125P23 (red), at the normal localization, but smaller than the one on the normal 1; the red signal on the long arms, both on the normal 1 and on the inv(1), is due do cross-hybridization, and the green signal is the one of probe RP11-90B12, flanking the MPL gene, used as internal control and displaced towards the centromere on the inv(1); B: the arrow indicates the signal of probe RP11-46G23 (red), moved towards the telomere on the inv(1); C: the arrow indicates the signal of probe RP11-690E2 (green), moved towards the centromere on the inv(1); D: the arrow indicates the inv(1) lacking the signal of probe RP11-372C15 (green, on the normal 1); the red signal is the one of probe RP11-113C10, flanking the MPL gene, used as internal control and displaced towards the centromere on the inv(1)

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