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Figure 4 | Molecular Cytogenetics

Figure 4

From: A novel dic (17;18) (p13.1;q11.2) with loss of TP53 and BCR/ABL rearrangement in an Imatinib resistant chronic myeloid leukemia

Figure 4

Gel electrophoresis of the DdeI restriction analysis on the ABL exon 7 and progressive appearance of the T315I point mutation. A single base change from C to T results in a fragment length polymorphism. The T315I mutation resulted in an uncut PCR product of 72 bps. Lines 1 and 4, 25 bp molecular weight markers; line 2, T315I mutation from the patient and line 3, normal control (K562 cell line).

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