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Figure 1 | Molecular Cytogenetics

Figure 1

From: Exosome-delivered microRNAs of “chromosome 19 microRNA cluster” as immunomodulators in pregnancy and tumorigenesis

Figure 1

(A) Partial karyotype of an adenoma with an apparently balanced translocation t(1;19)(q32;q13.4) is shown as an example of adenomas with a 19q13.4 chromosomal rearrangement. (B) Metaphase of a thyroid adenoma with a t(1;19)(q32;q13.4) after FISH with dual-color break-apart rearrangement probe appropriate for the detection of 19q13.4 rearrangements. The 19q13.4 rearrangement is indicated by one single green and one single red signal each. (C) The chromosomal region 19q13.4 with the miRNA clusters C19MC and miR-371-3 (pink boxes) and surrounding protein-coding genes (blue boxes). The common breakpoint cluster of thyroid adenomas and adenomatous goiters is indicated by an arrow.

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Molecular Cytogenetics

ISSN: 1755-8166