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Figure 2 | Molecular Cytogenetics

Figure 2

From: Juxtaposition of heterochromatic and euchromatic regions by chromosomal translocation mediates a heterochromatic long-range position effect associated with a severe neurological phenotype

Figure 2

Nuclear position of derivative chromosomes with beta satellite regions. i-FISH (top) performed using D15Z1 (green), GABRB3 (red) and RPC1-98 C19 (blue) containing beta-satellite DNA. The large and small arrows respectively indicate der(16) and der(15). Chromosome 15 is not shown but it occupies the region in which all three hybridization signals are located, with the green signal larger than those identified on the two derivatives. At the bottom left a drawing showing the expected hybridization pattern allowing to recognize the three different chromosomes (der (16), der (15) and chromosome 15) on nucleus. The picture above shows only the expected pattern of hybridization on the three chromosomes in the drawing below is also shown acrocentric regions recognized by the probe containing beta-satellite DNA. At the bottom right graphs A, B, and C show the rate of co-localisation of der(16) (dark grey) and der(15) (light grey) to the regions targeted by the beta satellite. The results average of three experiments is shown on the right.

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Molecular Cytogenetics

ISSN: 1755-8166