Nuclei with and without complex sSMC(18) derived from lymphocytes. A) Representative interphase nucleus for case 5. In the figure the position of the sSMC is highlighted (arrowhead) and the pseudocolors together with the applied probes are given. Chromosomes 19 are in close together and central, chromosomes 8 and 18 are in opposite orientation and peripheral positions, the sSMC is in central to intermediate position and colocalized to a chromosome 19. B) Representative interphase nucleus of case 6 using probe set for case 5. Chromosomes 19 are in close together and central to intermediate, chromosomes 8 and 18 are in peripheral and opposite positions. N.B. Animations of the corresponding nuclei are available as additional file - film 5.