Nuclei with and without sSMC(15) derived from T-lymphocytes. A) Representative interphase nucleus for case 1. In the figure the position of the sSMC is highlighted (arrowhead) and the pseudocolors together with the applied probes are given. One chromosomes 19 is central, the other peripheral positioned, both chromosomes 15 have similar positions as chromosomes 19. The sSMC is colocalized with the chromosomes 15 and 19 in central position. B) Representative interphase nucleus of case 6 using probe set for case 1. Chromosomes 19 are in close together and central, chromosomes 15 are in central to intermediate positions. N.B. Animations of the corresponding nuclei are available as additional file - film 1.