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Table 2 Cases in which microarray analysis did not detect aberrations identified by chromosome analysis or FISH

From: Evaluation of chronic lymphocytic leukemia by BAC-based microarray analysis

Case Karyotype FISH Percent Abnormal by FISH Array Results Size
3 47,XY,+12[3]/46,XY[16]/92,XXYY[1] nuc ish(CCND1,IGH@)x2 [202/202] 0 Arr(1-22)x2,(XY)x1  
   nuc ish(CD82,ATM)x2[199/200] 0   
   nuc ish(pBR12,APAF1)x3 [5/200] 2.5   
   nuc ish(D13S319,LAMP1)x2[204/204] 0   
   nuc ish(TP53,ERBB2)x2[200/200] 0   
4 46,XY,del(4)(p?15.2),del(11)(q21q23.3),add(14)(q32)[10]/46,XY[9] nuc ish(ATMx1), (KAI1x2)[ 74/200] 37.0 del chr11:101900200-113746962 (11q22.2q23.2) 11.8 Mb
   nuc ish(ATMx1),(KAI1x1)[8/200] 4.0   
   nuc ish(D13S319x1),(LAMP1x1)[31/235] 13.2   
   nuc ish(D13S319x1),(LAMP1x2) [110/235] 46.8 del chr13:48903923-49406099 (13q14.3q14.3) 502 kb
   nuc ish(5'IGHVx1,3'IGHx1)[7/227] 3.1   
   nuc ish(5'IGHVx2,3'IGHx2)(5'IGHV sep 3'IGHx1)[35/227] 15.4   
   nuc ish(5'IGHVx1,3'IGHx2)(5'IGHV sep 3'IGHx1)[40/227] 17.6   
   nuc ish( (TP53,ERBB2)x2[250/250] 0   
   nuc ish(MYCx3)[ 116/200] 58.0 dup chr8:124436106-146015567 (8q21.13q24.3) 21.6 Mb
     del chr4:16516563-30324345 (4p15.32p15.1) 13.8 Mb
     del chr7:81021736-96580930 (7q21.11q21.3) 15.5 Mb
7 46,XY,t(14;19)(q32.3;q13.2)[9]/46,XY[11] nuc ish(CD82,ATM)x2[199/200] 0   
   nuc ish(pBR12,APAF1)x2[199/200] 0   
   nuc ish(D13S319,LAMP1)x2[243/243] 0   
   nuc ish(CCND1,IGH@)x2[200/200] 0   
   nuc ish(TP53x1),17cen(x2)[10/202] 5.0   
     del chr14:105267349-106339477 (14q32.33q32.33) 170 kb
     del chr22:21330008-21570697 (22q11.22q11.22) 241 kb
8 46,XY,del(11)(q14q23)[4]/48,XY,+4,+inv(?18)(q21q23)[3]/46,XY[13] nuc ish(CD82x2),(ATMx1)[21/200] 10.5   
   nuc ish(Pbr12,APAF1)x2[ 199/200] 0   
   nuc ish(D13S319x1),(LAMP1x2)[90/201] 44.8 del chr13:47759453-49406099(13q14.2q14.3) 1.6 Mb
   nuc ish(CCND1,IGH@)x2[200/200] 0   
   nuc ish(TP53,ERBB2)x2[199/200] 0   
     dup chr4:1-191273063 Trisomy
     dup chr18:1-76117153 Trisomy
10 47,XY,+12[9]/46,XY[11] nuc ish(D11Z1x2),(ATMx3)[ 11/229] 4.8   
   nuc ish(DDIT3)x3[126/226] 55.8 up chr12:74345-132349534 Trisomy
   nuc ish(D13S319,LAMP1)x2[199/200] 0   
   nuc ish(CCND1,IGH@)x2[200/200] 0   
   nuc ish(TP53x1),17cen(x2)[11/213] 5.2   
     del chr22:21044595-21570697 (22q11.22q11.22) 526 kb
16 Previous Sideline: 47,XX,t(2;14)(p13;q32.1),+12[1]/46,XX[19] nuc ish(pBR12,APAF1)x3[3/202] 1.5 Arr(1-22,X)x2  
17 Previous Sideline: 45,XY,del(3)(q21q27),-8,del(8)(p10),add(?9) (p13),del(11)(q13q23),del(13)(q14q22),add(17)(p10)[1]/46,XY[30] nuc ish(CD82x2),(ATMx1)[6/200] 3.0 del chr11:84811642-124583747 (11q14.1q24.2) 39.8 Mb
   nuc ish(D13S319x1),(LAMP1x2)[44/243] 18.1 del chr13:46386690-57242066 (13q14.2q21.1) 10.9 Mb
   nuc ish(D13S319x0),(LAMP1x1 or 2)[33/243] 13.6   
   nuc ish(TP53x1),(ERBB2x2) [17/200] 8.5   
     dup chr2:44073-60812692 (2p25.3p16.1) 60.8 Mb
     del chr6:57972657-147822754 (6p11.2q24.3) 89.9 Mb
     del chr9:9839207-27863525 (9p23p21.2) 18.0 Mb
18 46,XY,t(3;11)(q21;p15)[,der(5)del(5)(q13q31)t(5;15)(q31;q13),r(?7)(p22q?22),der(15)t(5;15),-21[6]/46,XY[13] nuc ish(CD82,ATM)x2[200/200] 0   
   nuc ish(pBR12,APAF1)x2[200 of 200] 0   
   nuc ish(D13S319,LAMP1)x1[27/200] 13.5   
   nuc ish(D13S319x1),(LAMP1x2)[82/200] 41.0   
   nuc ish(CCND1,IGH@)x2[228/228] 0   
   nuc ish(TP53,ERBB2)x2[195/200] 2.5   
     del chr3:66524310-71438751 (3p14.1p14.1) 4.9 Mb
     del chr5:67408207-67790791 (5q13.1q13.1) 382 kb
     del chr5:76836011-180616147 (5q14.1q35.3) 104 Mb
     del chr7:2327342-54294538 (7p22.3p11.2) 54.2 Mb
     del chr7:81021736-96580930 (7q21.11q21.3) 15.6 Mb
     del chr7:102955780-158788150 (7q22.1q36.3) 55.8 Mb
     del chr21:41514980-46912065 (21q22.3q22.3) 5.4 Mb
24 46,XY[20] nuc ish(D11Z1,ATM)x2[213/213] 0   
   nuc ish(DDIT3)x2[229/229] 0   
   nuc ish(D13S319,LAMP1)x1[15/203] 7.4 del chr13:48903923-49406099 (13q14.3q14.3) 502.2 kb
   nuc ish(D13S319x1),(LAMP1x2)[155/203] 76.3   
   nuc ish(CCND1,IGH@)x2[223/223] 0   
   nuc ish(TP53x2),17cen(x2)[199/200] 0   
25 N.D. uc ish(D11Z1,ATM)x2[212/213] 0 Arr(1-22,X)x2  
   nuc ish(DDIT3)x2[204/204] 0   
   nuc ish(D13S319x1),(LAMP1x2)[13/217] 6.0   
   nuc ish(D13S319x0),(LAMP1x2)[30/217] 13.8   
   nuc ish(D13S319x0),(LAMP1x2)[30/217] 0   
   nuc ish(TP53x2),17cen(x2)[199/200] 0