Figure 3

Microarray results for cases with 13q14 deletions identified by FISH reveal insufficient coverage for the detection of small deletions. (A) Microarray plot for case 2. For this case, the CLL FISH panel showed ~78.5% of cells with a 13q14 deletion. A deletion was detected by microarray analysis, but the extent of that deletion cannot be defined owing to insufficient coverage on the BAC array. (B) Insufficient coverage for the BAC array does not permit determination of the involvement of MIR16-1 and MIR15A in the deletion shown in part A. (C) Microarray plot for case 25. For this case, the CLL FISH panel showed ~20% of cells with a 13q14 deletion using a probe specific to MIR16-1 and MIR15A. Insufficient BAC coverage on this array is likely responsible for the failed detection of a small deletion. Plots are arranged as in Figure 1A.