Table 2 Candidate genes for agenesis of corpus callosum
Publication | Deletion in 1qter | Proposed Candidate gene |
|---|---|---|
Van Bever et al, 2005[8] | 4.5 Mb in1q44 | Mapped within RSG7 |
Boland et al, 2007[9] | 3.5 Mb in1q44 | AKT3, ZNF238 |
Joris et al, 2008[10] | 6.9 Mb in1q44 | AKT3 strong candidate gene |
Van Bon et al, 2008[12] | 0.36 Mb in1q44 | C1orf100, ADSs, C1orf101 &C1orf121. AKT3 gene was excluded |
Poot et al, 2008[25] | 4.8 Mb in1q44 | AKT3, ZNF238 was not deleted Therefore AKT3 was rejected |
Orellana et al, 2009[11] | 1.1 Mb in1q44 | AKT3, ZNF238, C1orf100 |
Aktas et al, 2010[13] | 2.9 Mb and 2.7 Mb in1q44 | C1orf100 to C1orf121 Genes proximal to SMYD3 AKT3 was excluded |
Caliebe et al, 2010[14] | 0.44 Mb in1q44 | FAM36A, HNRPU, EFCAB2, KIF26B |
Osburn et al,2011[8] | Deletion in 1q42.13 to q44 | DISC1 |
Lall M et al,2011 [present study] | 0.9 Mb in1q44 | Genes proximal to SMYD3 AKT3 excluded |