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Figure 1 | Molecular Cytogenetics

Figure 1

From: DNA secondary structure is influenced by genetic variation and alters susceptibility to de novo translocation

Figure 1

Polymorphism of the PATRR11 affects de novo translocation frequency. (A) Classification of PATRR11s. Arrows indicate each arm of the palindromic sequences. Grey and black arrows indicate complementary strands. (B) Size and symmetry of the palindrome affects the de novo translocation frequency. Vertical axis indicates de novo translocation frequency in sperm. (C) Correlation between the translocation frequency and secondary structure-forming propensity of the PATRR analyzed in silico. Horizontal axis indicates the free energy necessary for transition from standard double strand DNA to a hairpin structure, while the vertical axis indicates the de novo translocation frequency in sperm. No statistically significant correlation between ΔG and translocation frequency was observed (r = 0.372, P = 0.323).

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Molecular Cytogenetics

ISSN: 1755-8166