Skip to main content
Figure 1 | Molecular Cytogenetics

Figure 1

From: Assessment of ERBB2 and EGFR gene amplification and protein expression in gastric carcinoma by immunohistochemistry and fluorescence in situ hybridization

Figure 1

ERBB2 and EGFR gene amplification and protein expression in gastric cancer samples. (A) Representative image showing ERBB2 gene amplification in a gastric adenocarcinoma sample analyzed by FISH. The ratio of red to green signal is greater than 2, indicative of ERBB2 gene amplification (magnification, 1000 ×). (B) Representative image showing ERBB2 protein expression analyzed by IHC in a poorly-differentiated gastric adenocarcinoma (IHC score, 3+; magnification, 200 ×). (C) Representative image showing EGFR gene amplification in a gastric adenocarcinoma sample analyzed by FISH. The green signal corresponds to chromosome 7, and the red signal corresponds to EGFR. EGFR gene amplification is visible as red clustering (magnification, 1000 ×). (D) Representative image showing EGFR protein expression analyzed by IHC in a poorly-differentiated gastric adenocarcinoma (IHC score, 3+; magnification, 200 ×).

Back to article page

Molecular Cytogenetics

ISSN: 1755-8166