Skip to main content
Figure 2 | Molecular Cytogenetics

Figure 2

From: Two siblings with immunodeficiency, facial abnormalities and chromosomal instability without mutation in DNMT3B gene but liability towards malignancy; a new chromatin disorder delineation?

Figure 2

Chromosome aberrations detected by GTG-banding in P1 and P2: A-C) Aberrations including chromosome 1 like isochromosomes, derivative chromosomes and chromosome breaks. D) Chromatide exchange between chromosomes 1 and 10 with formation of triradial tr(1;10)(q12;q25). E-F) Aberrations of chromosome 2 like triradial chromosome 2 with 2q-arm duplication and isochromosomes 2. G-H) Isochromosomes 5q together with derivative chromosomes 5p. I) A chromatide exchange between chromosomes X and 5 led to formation of a triradial tr(X;5)(p13;p11~21). J) An isochromosome 7q was formed. K) Despiralization and fragmentation of chromosome 9. L-M) Isochromosome and chromatid-break involving chromosome 11. N-O) Chromatid-break events in chromosome 16 and X. P) Isochromosome Xq-formation.

Back to article page