Table 2 Results of various FISH probes application with MN test

-

Both chromosome breakage and loss

Genotoxicity testing or biomonitoring of genotoxic exposure and effect

[16–26]

Discrimination of aneugenic and clastogenic effects in vitro

[84–87]

Centromeric

MN with whole chromosomes

Discrimination of aneugenic and clastogenic effects in vivo

[88–92]

Biomarker of radiation exposure in vivo

[93]

Frequency of occurrence of chromosomes in spontaneously occurring MN

[106, 107]

Chromosome-specific centromeric

Whole chromosomes in MN and non-disjunctional events

Comparative sensitivity of different chromosomes toward mutagens

[96, 108, 109]

Study of mechanisms of aneuploidy

[72, 94–98]

Chromosome-locus-specific

MN with chromosome loci

Nature of genome instability in tumor cells

[75]

Distribution of radiation and chemical mutagen-induced cytogenetic damage

[74, 79, 105, 110]

WCP

Both whole chromosomes and acentric fragments in MN

Composition of spontaneous and mutagen-induced MN

[39, 76, 79, 81]

Composition of spontaneous MN in cells of patients with ICF

[73]

Selected probes

Different genomic regions in MN

Elucidation of MN formation

[72, 82, 83]