Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 3 Data on sporadic aneuploidy in different human tissues (presumably normal) depending on techniques used for the evaluation

From: Human interphase chromosomes: a review of available molecular cytogenetic technologies

Tissue Technique Aneuploidy rate Refs
Ovarian tissues I-FISH with site-specific probes Statistically significant proportion of aneuploid cells (trisomy 21) [109]
Chorionic villi mFISH/QFISH
ICS-MCB
~24% (~1% per chromosome) [21, 24, 35]
Fetal human brain mFISH/QFISH
ICS-MCB
~30% (~1.5% per chromosome)
~35% + confined mosaicism
[22, 24, 35]
Blood I-FISH with centromeric probes Chromosome X: 1.5%-2.5% and 4.5%-5%*; Autosomes: 1.2% and 1% [110]
  mFISH/QFISH Chromosome X: 1.11%;
Autosomes: 0,73%
[25]
Skin mFISH 2,2% and 4,4%* (whole genome -- over 50%) [111]
Liver mFISH ~3% (whole genome -- over 50%) [112]
Adult human brain mFISH/QFISH
ICS-MCB
~10% (~0.5% per chromosome) [20, 22, 23, 26, 28, 29]
  1. * - in young and old individuals, respectively;