Table 3 Data on sporadic aneuploidy in different human tissues (presumably normal) depending on techniques used for the evaluation

Ovarian tissues

I-FISH with site-specific probes

Statistically significant proportion of aneuploid cells (trisomy 21)

[109]

Chorionic villi

mFISH/QFISH

ICS-MCB

~24% (~1% per chromosome)

[21, 24, 35]

Fetal human brain

mFISH/QFISH

ICS-MCB

~30% (~1.5% per chromosome)

~35% + confined mosaicism

[22, 24, 35]

Blood

I-FISH with centromeric probes

Chromosome X: 1.5%-2.5% and 4.5%-5%*; Autosomes: 1.2% and 1%

[110]

mFISH/QFISH

Chromosome X: 1.11%;

Autosomes: 0,73%

[25]

Skin

mFISH

2,2% and 4,4%* (whole genome -- over 50%)

[111]

Liver

mFISH

~3% (whole genome -- over 50%)

[112]

Adult human brain

mFISH/QFISH

ICS-MCB

~10% (~0.5% per chromosome)

[20, 22, 23, 26, 28, 29]