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Table 1 Aneuploidy in the developing and normal adult human brain

From: GIN'n'CIN hypothesis of brain aging: deciphering the role of somatic genetic instabilities and neural aneuploidy during ontogeny

  Rate of aneuploidy, %
(per chromosome/whole genome)
Evaluation technique References
Developing brain:    
direct evaluation 0.6-3.0/~28 mFISH [9]
  1.25-1.45/30-35 mFISH/QFISH ICS-MCB [28]
after in vitro cultivation 1.2-7.0/72.4 mFISH [9, 27]
Adult brain:    
  0.1-0.8/~9 mFISH [9, 11]
  0.2-2/10 ICS-MCB [10]
  0.2-0.7/~10 mFISH/QFISH ICS-MCB [14]
  1. Abbreviations: mFISH -- multiprobe fluorescence in situ hybridization; QFISH -- quantitative fluorescence in situ hybridization; ICS-MCB -- interphase chromosome-specific multicolor chromosome banding.