GIN'n'CIN hypothesis of brain aging: deciphering the role of somatic genetic instabilities and neural aneuploidy during ontogeny

Table 1 Aneuploidy in the developing and normal adult human brain

	Rate of aneuploidy, % (per chromosome/whole genome)	Evaluation technique	References
Developing brain:
direct evaluation	0.6-3.0/~28	mFISH	[9]
	1.25-1.45/30-35	mFISH/QFISH ICS-MCB	[28]
after in vitro cultivation	1.2-7.0/72.4	mFISH	[9, 27]
Adult brain:
	0.1-0.8/~9	mFISH	[9, 11]
	0.2-2/10	ICS-MCB	[10]
	0.2-0.7/~10	mFISH/QFISH ICS-MCB	[14]

Abbreviations: mFISH -- multiprobe fluorescence in situ hybridization; QFISH -- quantitative fluorescence in situ hybridization; ICS-MCB -- interphase chromosome-specific multicolor chromosome banding.

ISSN: 1755-8166