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Figure 1 | Molecular Cytogenetics

Figure 1

From: Candidate metastasis suppressor genes uncovered by array comparative genomic hybridization in a mouse allograft model of prostate cancer

Figure 1

Heat map of oligonucleotide array CGH results. Array CGH results are partitioned by chromosome number and clustered by probe location in the chromosomes. The length of each chromosome bar is based on the total number of probes for that chromosome present on the array. Within each chromosome bar, each row represents a separate NE-10 tumor, and the non-metastatic tumors (SQnon-Met) are separated from the metastatic tumors (LiverMet) by the white line (SQnon-Met above and LiverMet below the line). Black represents normal copy number in tumor compared to the normal reference; red represents increased copy number; green represents decreased copy number. A larger interstitial deletion in chromosome 2 can be visualized in the metastatic compared to the non-metastatic tumors (blue box). Relative loss of the X chromosome in the metastatic tumors, and most of the X chromosome in the non-metastatic tumors, is seen because array CGH for these tumor samples was performed using a sex-mismatched (female) reference DNA. The non-metastatic tumors also show a region of copy number gain on the X chromosome.

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Molecular Cytogenetics

ISSN: 1755-8166