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Table 1 Proportion of T21 cell nuclei in foetal ovaries identified by two chromosome 21-specific probes

From: On the origin of trisomy 21 Down syndrome

   T21 cells (%)  
Case No/Id Gest. Age (wks) Meiotic prophase germ cells Pre-meiotic germ and stroma cells Total (%)
1/C14 17 8/1287 (0.62) 6/637 (0.94) 14/1924 (0.68)
2/C19 18 4/753 (0.53) 2/311 (0.64) 6/1064 (0.56)
3/C17 19 9/1221 (0.74) 7/603 (1.16) 16/1824 (0.88)
4/C11 19 3/392 (0.77) 2/575 (0.35) 5/967 (0.52)
5/F8799 13    6/1578 (0.77)
6/1C 15    2/1048 (0.20)
7/2D 15    6/2029 (0.30)
8/3D 22    13/2200 (0.59)
Average   24/3653 (0.66) 17/2126 (0.80) 68/12634 (0.54)
  1. Note: In cases 1–4 the proportion of germ cells entering meiotic prophase was pre-identified by the meiosis-specific protein STAG3 before the FISH analysis of chromosome 21 copy numbers.