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Figure 1 | Molecular Cytogenetics

Figure 1

From: FISH mapping of Philadelphia negative BCR/ABL1 positive CML

Figure 1

Summary of the FISH mapping carried out on Ph negative BCR/ABL1 positive bone marrow cells from 9 CML patients and the cell line CML-T1. Header row shows the location of BCR/ABL1 fusion: 22q11.2 (cases no 1–6), 22p (case 7) and 9q34.1 (cases 8–10). (a) Map of the 9q34.1-qter region with coloured squares (key on the right) indicating the location or deletion of the BAC clones used for FISH analysis (approximate genomic distances to the breakpoint and names of the BAC clones on the left). A thick black horizontal line presents the ABL1 breakpoint, which is encompassed by the clones RP11-57C19 and RP11-83J21. When a breakpoint falls within a BAC, the probe gives a split signal in two different locations. (b) Map of the 22q11.2 region with coloured squares (key below) indicating the location or deletion of the BAC clones tested (genomic distances and names of the clones on the left). A thick black horizontal line presents the BCR breakpoint, which falls within the BAC clone RP11-164N13.

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