Alain Bernheim, Chromosome condensation and sequence
30 April 2009
This superb paper clearly demonstrates a condensation asymetry between R and G bands that are intimely linked to the functionnal structure of the genome. It shows also that chromosome banding and sequence are not mathematicaly linked. There is a need to address the exact localization and spliting of tiling probes (BAC or smaller) on human genomes (male and female) to assign each bit of the complete sequence to the metaphasic and interphasic chromosomes in detail. This huge project is technically feasible via a consortium. But will be a scientific mobilisation ?
Molecular Cytogenetics
From the proof of concept to the application
30 April 2009
This superb paper clearly demonstrates a condensation asymetry between R and G bands that are intimely linked to the functionnal structure of the genome. It shows also that chromosome banding and sequence are not mathematicaly linked.
There is a need to address the exact localization and spliting of tiling probes (BAC or smaller) on human genomes (male and female) to assign each bit of the complete sequence to the metaphasic and interphasic chromosomes in detail. This huge project is technically feasible via a consortium. But will be a scientific mobilisation ?
Competing interests
no